Assessing Graves%26apos; ophthalmopathy-specific quality of life in Korean patients

作者：Choi Y J; Lim H T; Lee S J; Lee S Y; Yoon J S^*

来源：Eye, 2012, 26(4): 544-551.

DOI：10.1038/eye.2011.359

• Graves%26apos
• ophthalmopathy
• quality of life
• questionnaire

Aim To investigate the clinical significance of Grave%26apos;s ophthalmopathy-specific quality of life (GO-QOL) in Korean patients. %26lt;br%26gt;Methods A cross-sectional study was conducted at the Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea, on 98 consecutive Grave%26apos;s ophthalmopathy (GO) patients. The GO-QOL survey provided by Terwee and colleagues and suggested by the European group on Graves%26apos; orbitopathy (EUGOGO) was translated into Korean language and distributed to study participants. Clinical severity was judged by scores of the modified NOSPECS classification, and inflammatory activity was measured by a seven-point scale of clinical activity score (CAS). %26lt;br%26gt;Results The mean GO-QOL scores were 73.7 (standard deviation (SD), 26) for visual functioning, 61.9 (SD 26) for appearance, and 67.8 for total quality of life (QOL; SD 22). The worse QOL scores for each part were significantly associated with the higher modified NOSPECS score and CAS after adjusting for confounders such as age and sex (P %26lt; 0.05, respectively). In particular, decreased QOL scores for visual function were significantly correlated with a higher grade of extraocular muscle involvement (P %26lt; 0.05). Lower QOL scores for appearance were associated with more severe soft-tissue involvement and proptosis (P %26lt; 0.05, respectively). %26lt;br%26gt;Conclusions GO-QOL suggested by EUGOGO showed correlation with objective clinical parameters. GO-QOL can be a simple and effective tool in the evaluation of the clinical and psychological illness of GO patients. Eye (2012) 26, 544-551; doi:10.1038/eye.2011.359; published online 13 January 2012

• 出版日期2012-4