MicroRNAs-449a and-449b exhibit tumor suppressive effects in retinoblastoma

作者：Martin Alissa; Jones Aunica; Bryar Paul J; Mets Marilyn; Weinstein Joanna; Zhang Gang; Laurie Nikia A^*

来源：Biochemical and Biophysical Research Communications, 2013, 440(4): 599-603.

DOI：10.1016/j.bbrc.2013.09.117

• MicroRNA
• Retina
• Retinoblastoma
• Proliferation
• Apoptosis

Retinoblastoma is the most common pediatric cancer of the eye. Currently, the chemotherapeutic treatments for retinoblastoma are broad-based drugs such as vincristine, carboplatin, or etoposide. However, therapies targeted directly to aberrant signaling pathways may provide more effective therapy for this disease. The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. This study suggests that these miRNAs could serve as viable therapeutic targets for retinoblastoma treatment.

• 出版日期2013-11-1
• 单位西北大学