Associations between prenatal traffic-related air pollution exposure and birth weight: Modification by sex and maternal pre-pregnancy body mass index

作者：Lakshmanan Ashwini; Chiu Yueh Hsiu Mathilda; Coull Brent A; Just Allan C; Maxwell Sarah L; Schwartz Joel; Gryparis Alexandros; Kloog Itai; Wright Rosalind J; Wright Robert O

来源：Environmental Research, 2015, 137: 268-277.

DOI：10.1016/j.envres.2014.10.035

• Traffic-related air pollution
• Prenatal exposure
• Birth weight
• Sex
• Body mass index

Background: Prenatal traffic-related air pollution exposure is linked to adverse birth outcomes. However, modifying effects of maternal body mass index (BMI) and infant sex remain virtually unexplored.
Objectives: We examined whether associations between prenatal air pollution and birth weight differed by sex and maternal BMI in 670 urban ethnically mixed mother-child pairs.
Methods: Black carbon (BC) levels were estimated using a validated spatio-temporal land-use regression (LUR) model; fine particulate matter (PM2.5) was estimated using a hybrid LUR model incorporating satellite-derived Aerosol Optical Depth measures. Using stratified multivariable-adjusted regression analyses, we examined whether associations between prenatal air pollution and calculated birth weight for gestational age (BWGA) z-scores varied by sex and maternal pre-pregnancy BMI.
Results: Median birth weight was 3.3 +/- 0.6 kg; 33% of mothers were obese (BMI >= 30 kg/m(3)). In stratified analyses, the association between higher PM2.5 and lower birth weight was significant in males of obese mothers (-0.42 unit of BWGA z-score change per IQR increase in PM2.5, 95%CI: -0.79 to -0.06) (PM2.5 x sex x obesity P-interaction=0.02). Results were similar for BC models (P-interaction=0.002).
Conclusions: Associations of prenatal exposure to traffic-related air pollution and reduced birth weight were most evident in males born to obese mothers.

• 出版日期2015-2