Association between cigarette smoking and interleukin-17A expression in nasal tissues of patients with chronic rhinosinusitis and asthma

作者：Huang Chien Chia; Wang Chun Hua; Fu Chia Hsiang; Huang Chi Che; Chang Po Hung; Chen Yi Wei; Wu Chia Chen; Wu Pei Wen; Lee Ta Jen^*

来源：Medicine, 2016, 95(47): e5432.

DOI：10.1097/MD.0000000000005432

• asthma
• chronic rhinosinusitis
• cigarette smoking
• interleukin-17A
• nasal tissue

Cigarettesmoke plays a substantial role in the development of airway inflammatory diseases, including asthma and chronic rhinosinusitis (CRS). Interleukin (IL)-17A might contribute to cigarette smoke-related inflammation of the airway. This study aimed to investigate the association between cigarette smoking and IL-17A expression in the nasal tissues of patients with CRS and asthma.
We prospectively recruited 24 patients (13 smokers, 11 nonsmokers) with CRS and asthma and 6 patients with asthma but without CRS (control group) in a tertiary medical center. Nasal mucosa was obtained as part of the nasal surgery. Protein and mRNA levels of IL-17A in the nasal tissues were determined by immunostaining and real-time polymerase chain reaction.
The number of unexpected emergency clinic visits for acute asthma attacks were higher among smokers than among nonsmokers. Interleukin-17A protein and mRNA levels in the nasal tissues of smokers were greater compared to those in the nasal tissues of nonsmokers (P=0.02 both) and control patients (P=0.05 and 0.04, respectively).
Cigarette smoking was associated with an increase in the number of unexpected emergency clinic visits due to acute asthma attack and in the expression of IL-17A in the nasal tissues of patients with airway inflammatory diseases.

• 出版日期2016-11
• 单位长春大学