Histone H2A Monoubiquitination in Neurodevelopmental Disorders

作者：Srivastava Anshika; McGrath Brian; Bielas Stephanie L

来源：Trends in Genetics, 2017, 33(8): 566-578.

DOI：10.1016/j.tig.2017.06.002

Covalent histone modifications play an essential role in gene regulation and cellular specification required for multicellular organism development. Monoubiquitination of histone H2A (H2AUb1) is a reversible transcriptionally repressive mark. Exchange of histone H2A monoubiquitination and deubiquitination reflects the succession of transcriptional profiles during development required to produce cellular diversity from pluripotent cells. Germ-line pathogenic variants in components of the H2AUb1 regulatory axis are being identified as the genetic basis of congenital neurodevelopmental disorders. Here, we review the human genetics findings coalescing on molecular mechanisms that alter the genome-wide distribution of this histone modification required for development

• 出版日期2017-8