Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia

作者：Novak Gabriela; LeBlanc Martha; Zai Clement; Shaikh Sajid; Renou Julien; DeLuca Vincenzo; Bulgin Natalie; Kennedy James L; Le Foll Bernard^*

来源：Annals of Human Genetics, 2010, 74: 291-298.

DOI：10.1111/j.1469-1809.2010.00578.x

• Schizophrenia
• nicotine
• addiction
• dopamine
• polymorphism
• association
• gene
• genetic susceptibility
• association analysis
• BDNF
• DRD1
• DRD3
• smoking

P>Emerging evidence indicates that the DRD1-BDNF-DRD3 cluster plays an important role in nicotine addiction. We have performed an association analysis of 42 SNPs within these genes with cigarette consumption in a group of 341 schizophrenia patients. The ACCG haplotype consisting of four BDNF markers (Val66Met (rs6265), rs11030104, rs2049045 and rs7103411) showed an association with the risk of smoking (p = 0.0002). Both DRD1 markers tested (rs4532 and rs686) and the DRD3 marker (rs1025398) showed association with quantity of tobacco smoked (p = 0.01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour.

• 出版日期2010-7
• 单位河北医科大学