A neural network model for estimating O-2 absorption coefficient in shake-flasks

作者：Liu YC^*; Chang H; I YP

来源：Biotechnology Letters, 2000, 22(23): 1885-1888.

• mathematical model
• neural network model
• oxygen absorption coefficient
• shake-flask

A comprehensive, simple, neural network model was constructed to replace the common semi-empirical mathematical models used for predicting individual O-2 absorption coefficients (K(L)a) within Erlenmeyer and Hinton shake-flasks. Different factors that influence K(L)a within shake-flasks, such as flask dimensions, working volumes, baffle-heights, and shaking speeds, were investigated and the experimental results employed to deduce the mathematical model for each type of shake-flask. Meanwhile, the K(L)a values calculated from the mathematical models were used to derive a non-linear neural network estimator (NNE). The NNE for K(L)a prediction was implemented to evaluate the O-2 absorption effect within the flasks and gave a promising result.

• 出版日期2000-12