A bio-inspired enantioselective small-molecule artificial receptor for beta adrenergic agonists and antagonists and its application for enantioselective extraction

作者:de Arriba Angel L Fuentes*; Simon Luis; Rubio Omayra H; Monleon Laura M; Alcazar Victoria; Sanz Francisca; Raposo Cesar A; Moran Joaquin R*
来源:Chemical Communications, 2016, 52(85): 12582-12585.
DOI:10.1039/c6cc06281d

摘要

Administration of enantiomerically pure beta-adrenergic agonists and antagonists increases their activity and reduces side effects. We report here a small-molecule artificial receptor (SMAR) that, by mimicking the beta-adrenergic receptor, is able to enantioselectively extract commercial beta-adrenergic interacting drugs. The selectivity is justified according to DFT calculations and X-ray diffraction experiments.

  • 出版日期2016