科研之友
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摘要
Two different dicarboxylic acids (glutamic acid and succinic acid), instead of acetic acid, were used simultaneously as solubilizing and crosslinking agents in the preparation of chitosan-based hydrogel. Sustained, homogeneous and transparent hydrogels were formed with amide linkage formations. X-ray diffraction and Fourier transformed infrared (FTIR) were used to examine the crystal structure and chemical composition of chitosan/glutamic acid (C/G) hydrogel and chitosan/ succinic acid (C/S) hydrogel, respectively. The in vitro cell cultures confirmed that the amine group was effective in promoting cell affinity. Histological examinations revealed that reepithelialization and regeneration of tissue was achieved 50% faster by dressing the wound with the C/G hydrogels. This chitosan/dicarboxylic acid hydrogel system has potential as wound dressing material.
- 出版日期2011-9
