Systemic Cytokine Profiles in Strongyloides stercoralis Infection and Alterations following Treatment

作者：Anuradha Rajamanickam; Munisankar Saravanan; Bhootra Yukti; Jagannathan Jeeva; Dolla Chandrakumar; Kumaran Paul; Shen Kui; Nutman Thomas B; Babu Subash

来源：Infection and Immunity, 2016, 84(2): 425-431.

DOI：10.1128/IAI.01354-15

<jats:p><jats:named-content content-type="genus-species">Strongyloides stercoralis</jats:named-content>is a soil-transmitted helminth organism that infects ∼50 to 100 million people worldwide. Despite its widespread prevalence, very little is known about the immune response that characterizes human<jats:named-content content-type="genus-species">S. stercoralis</jats:named-content>infection. To study the systemic cytokine profile characteristic of<jats:named-content content-type="genus-species">Strongyloides</jats:named-content>infection, we measured the circulating levels of a large panel of pro- and anti-inflammatory cytokines in asymptomatic, infected individuals (<jats:italic>n</jats:italic>= 32) and compared them to those in uninfected, controls (<jats:italic>n</jats:italic>= 24). Infected individuals exhibited significantly lower circulating levels of proinflammatory cytokines (gamma interferon [IFN-γ], tumor necrosis factor alpha [TNF-α], and interleukin-1β [IL-1β]) and significantly higher levels of anti-inflammatory cytokines (IL-4, IL-5, IL-9, IL-10, IL-13, IL-27, IL-37, and transforming growth factor β [TGF-β]). Moreover, treatment of<jats:named-content content-type="genus-species">Strongyloides</jats:named-content>infection resulted in a significant reversal of the cytokine profile, with increased levels of proinflammatory (IFN-γ, TNF-α, IL-2, IL-17A, IL-17F, IL-22, IL-23, and IL-1β) and decreased levels of anti-inflammatory (IL-4, IL-5, IL-9, IL-10, IL-13, IL-27, IL-37, and TGF-β) cytokines following treatment. Thus,<jats:named-content content-type="genus-species">S. stercoralis</jats:named-content>infection is characterized by alterations in the levels of systemic cytokines, reflecting major alterations in the underlying immune response to this chronic helminth infection.</jats:p>

• 出版日期2016-2