Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence

作者：Dou, Ruoxu; Ng, Kimmie; Giovannucci, Edward L.; Manson, Joann E.; Qian, Zhi Rong; Ogino, Shuji^*

来源：British Journal of Nutrition, 2016, 115(9): 1643-1660.

DOI：10.1017/S0007114516000696

• 25-Hydroxyvitamin D
• P450 hydroxylases
• Vitamin D supplementation

In many cells throughout the body, vitamin D is converted into its active form calcitriol and binds to the vitamin D receptor (VDR), which functions as a transcription factor to regulate various biological processes including cellular differentiation and immune response. Vitamin D-metabolising enzymes (including CYP24A1 and CYP27B1) and VDR play major roles in exerting and regulating the effects of vitamin D. Preclinical and epidemiological studies have provided evidence for anti-cancer effects of vitamin D (particularly against colorectal cancer), although clinical trials have yet to prove its benefit. In addition, molecular pathological epidemiology research can provide insights into the interaction of vitamin D with tumour molecular and immunity status. Other future research directions include genome-wide research on VDR transcriptional targets, gene-environment interaction analyses and clinical trials on vitamin D efficacy in colorectal cancer patients. In this study, we review the literature on vitamin D and colorectal cancer from both mechanistic and population studies and discuss the links and controversies within and between the two parts of evidence.

• 出版日期2016-5-14
• 单位中山大学