Association of PPAR gamma 2 polymorphisms with carcass and meat quality traits in a Pietrain x Jinhua F2 population

作者：Chen, Zhe; Zhao, Xiaofeng; Jiang, Xiaoling; Guo, Xiaoling; Lv, Zunzhou; Zhou, Hongmei; Xu, Ningying^*

来源：Genetics and Molecular Biology, 2011, 34(1): 56-61.

DOI：10.1590/S1415-47572010005000107

• PPAR gamma 2 gene
• haplotype
• carcass and meat quality
• pigs

The PPAR gamma 2 gene is a key regulator of both proliferation and preadipocyte differentiation in mammals. Herein its genotype and allele frequencies were analyzed using PCR-SSCP in eight pig breeds (N = 416). Two kinds of polymorphisms of the PPAR gamma 2 gene were detected, including a previously reported shift SNP A177G (Met59Val) in exon 1 and a novel silent mutation G876A in exon 5. The results revealed that European pig breeds carry a higher allele A frequency at the A177G locus and a fixed GG genotype at the G876A locus. Allele A at the G876A locus was only found in Jinhua pigs. The association between haplotype (A177G/G876A) and carcass and meat quality traits was analyzed in a Pietrain x Jinhua F2 population (N = 248). The PPAR gamma 2 gene was found to be significantly associated with backfat thickness at the shoulder (p < 0.05), 6-7(th) ribs (p < 0.01), last rib (p < 0.01), gluteus medius (p < 0.05) and ham weight (p < 0.01). Significant effects of different haplotypes on ham weight and backfat thickness at the 6-7(th) ribs, last rib, and gluteus medius were also observed.

• 出版日期2011
• 单位浙江大学; 杭州师范大学