Age-related dendritic hypertrophy and sexual dimorphism in rat basolateral amygdala

作者：Rubinow Marisa J; Drogos Lauren L; Juraska Janice M^*

来源：Neurobiology of Aging, 2009, 30(1): 137-146.

DOI：10.1016/j.neurobiolaging.2007.05.006

• Aging
• Basolateral nucleus
• Dendrites
• Dendrites
• Dendritic spines
• Golgi-Cox
• Sex difference

Little research has examined the influence of, aging of. sex oil anatomical measures ill the basolateral amygdala. We quantified spine density and dendritic material in Golgi-Cox stained tissue of the basolateral nucleus in young adult (3-5 months) and aged (20-24 months) male and female Long-Evans rats. Dendritic branching and spine density were measured in principal neurons. Age, but not sex, influenced the dendritic tree, with aged animals displaying significantly more dendritic material. Previous findings from our laboratory in the same set of subjects indicate an opposite effect of aging on dendritic material in the medial prefrontal cortex and hippocampus. We also report here a sex difference across ages in dendritic spine density, favoring males.

• 出版日期2009-1