An Event-Related Potential Study of Response Inhibition in ADHD With and Without Prenatal Alcohol Exposure

作者：Burden Matthew J; Jacobson Joseph L; Westerlund Alissa; Lundahl Leslie H; Morrison Audrey; Dodge Neil C; Klorman Rafael; Nelson Charles A; Avison Malcolm J; Jacobson Sandra W^*

来源：Alcoholism: Clinical and Experimental Research , 2010, 34(4): 617-627.

DOI：10.1111/j.1530-0277.2009.01130.x

• Fetal Alcohol Spectrum Disorders
• Prenatal Alcohol Exposure
• Response Inhibition
• Event-Related Potentials
• Attention Deficit Hyperactivity Disorder

Background:
The attention and cognitive problems seen in individuals with a history of prenatal alcohol exposure often resemble those associated with attention deficit hyperactivity disorder (ADHD), but few studies have directly assessed the unique influence of each on neurobehavioral outcomes.
Methods:
We recorded event-related potentials (ERPs) during a Go/No-go response inhibition task in young adults with prospectively obtained histories of prenatal alcohol exposure and childhood ADHD.
Results:
Regardless of prenatal alcohol exposure, participants with childhood ADHD were less accurate at inhibiting responses. However, only the ADHD group without prenatal alcohol exposure showed a markedly diminished P3 difference between No-go and Go, which may reflect a more effortful strategy related to inhibitory control at the neural processing level.
Conclusion:
This finding supports a growing body of evidence suggesting that the manifestation of idiopathic ADHD symptoms may stem from a neurophysiologic process that is different from the ADHD symptomatology associated with prenatal alcohol exposure. Individuals who have been prenatally exposed to alcohol and present with ADHD symptomatology may represent a unique endophenotype of the disorder, which may require different treatment approaches from those found to be effective with idiopathic ADHD.

• 出版日期2010-4