A unique scaffold for bone tissue engineering: An osteogenic combination of graphene oxide-hyaluronic acid-chitosan with simvastatin

作者：Unnithan Afeesh Rajan; Sasikala Arathyram Ramachandra Kurup; Park Chan Hee; Kim Cheol Sang

来源：Journal of Industrial and Engineering Chemistry, 2017, 46: 182-191.

DOI：10.1016/j.jiec.2016.10.029

• Graphene oxide
• Chitosan
• Hyaluronic acid
• Simvastatin
• Bone tissue engineering

The present study explores the first ever fabrication of graphene oxide (GO)Chitosan (CS)Hyaluronic acid (HA) based bioactive composite scaffold containing an osteogenesis-inducing drug simvastatin (SV) for bone tissue engineering application. Porosity, density, swelling, degradation and biomineralization studies favored the SV loaded GOCSHA scaffold in comparison to the conventional CS and HA based scaffolds. The in vitro results showed that the SV also offers a significant influence on osteogenesis and biomineralization and it possess excellent biocompatibility to be used as a bone tissue engineering scaffold, which is able to persuade osteogenesis and mineralization.

• 出版日期2017-2-25