A Substantial Transmission Bottleneck among Newly and Recently HIV-1-Infected Injection Drug Users in St Petersburg, Russia

作者：Masharsky Alexey E; Dukhovlinova Elena N; Verevochkin Sergei V; Toussova Olga V; Skochilov Roman V; Anderson Jeffrey A; Hoffman Irving; Cohen Myron S; Swanstrom Ronald; Kozlov Andrei P^*

来源：Journal of Infectious Diseases, 2010, 201(11): 1697-1702.

DOI：10.1086/652702

There are limited data on the genetic complexity of human immunodeficiency virus type 1 (HIV-1) after transmission among a cohort of injection drug users (IDUs). We used single-genome amplification of HIV-1 env to determine the genotypic characteristics of virus among IDUs with acute infection in St Petersburg, Russia. Our results indicate that a single variant was transmitted in a majority of cases (9 of 13 participants), which is analogous to what is observed in sexual transmission. These data are most consistent with a genetic bottleneck during transmission by injection drug use that is due to a small inoculum, which most often results in the transmission of a low-complexity viral population.

• 出版日期2010-6-1