Alpha-synuclein, lipids and Parkinson's disease

作者：Ruiperez Violeta; Darios Frederic; Davletov Bazbek^*

来源：Progress in Lipid Research, 2010, 49(4): 420-428.

DOI：10.1016/j.plipres.2010.05.004

• Alpha-synuclein
• Arachidonic acid
• Docosahexaenoic acid
• Lipids
• Lipid peroxidation
• Mitochondria
• Oxidative stress
• Parkinson's disease
• Polyunsaturated fatty acids

Parkinson's disease is the second most common neurodegenerative disease, after Alzheimer's disease, among the aging human population. The main symptoms of Parkinson's disease such as tremor and movement disabilities are the result of degeneration of dopaminergic neurons in substantia nigra pars compacta. The widely-accepted subcellular factor which underlies Parkinson's disease neuropathology is the presence of Lewy bodies with characteristic inclusions of aggregated alpha-synuclein. This small soluble protein has been implicated in a range of interactions with phospholipid membranes and free fatty acids. The precise biological function of this protein is, however, still under investigation. Here we review the evidence linking alpha-synuclein, lipid metabolism, fatty acid oxidation, mitochondrial damage and Parkinson's disease. We propose that association of alpha-synuclein with oxidized lipid metabolites can lead to mitochondrial dysfunction in turn leading to dopaminergic neuron death and thus to Parkinson's disease.

• 出版日期2010-10