Association analyses of depression and genes in the hypothalamus-pituitary-adrenal axis

作者：Buttenschon Henrietta Normolle^*; Krogh Jesper; Nielsen Marit Nyholm; Kaerlev Linda; Nordentoft Merete; Mors Ole

来源：ACTA NEUROPSYCHIATRICA, 2017, 29(1): 59-64.

DOI：10.1017/neu.2016.26

• angiotensin converting enzyme (ACE)
• association
• depression
• hypothalamus-pituitary-adrenal (HPA) axis
• single nucleotide polymorphism (SNP)

Objective Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been reported in depression. The aim was to investigate the potential association between depression and seven genes regulating or interfering with the HPA axis, including the gene encoding angiotensin converting enzyme (ACE).
Methods In total, 78 single nucleotide polymorphisms (SNPs) and one insertion/deletion polymorphism were genotyped. The study included 408 individuals with depression and 289 controls. In a subset of cases, the interaction between genetic variants and stressful life events (SLEs) was investigated.
Results After quality control, 68 genetic variants were left for analyses. Four of nine variants within ACE were nominally associated with depression and a gene-wise association was likewise observed. However, none of the SNPs located within AVP, CRH, CRHR1, CRHR2, FKBP5 or NC3C1 were associated with depression. One nominally significant interaction, most likely due to chance, was identified.
Conclusion The results indicate that ACE could be a potential candidate gene for depression.

• 出版日期2017-2
• 单位上海市精神卫生中心