Direct formation of cyclobutenylphosphonates from 1-alkynylphosphonates and Cp2ZrCl2/2EtMgCl/2CuCl

作者：Sineinikove Yulia; Rubinstein Abraham; Srebnik Morris^*; Al Quntar Abed Al Aziz

来源：Tetrahedron Letters, 2009, 50(8): 867-869.

DOI：10.1016/j.tetlet.2008.11.108

• Alkynylphosphonates
• Cyclization
• Cyclobutenylphosphonates
• Diethylzirconocene
• Copper chloride

Zirconacycles 2 prepared from 1-alkynylphosphonates 1, zirconocene dichloride, and 2 equiv of EtMgCl are smoothly converted into cyclobutenylphosphonates 3 when treated with two equiv of CuCl in 65-81% isolated yield. The reaction is specific and general only for zirconacyclopentenyl phosphonates.

• 出版日期2009-2-25