Nonlinear Exercise Training in Advanced Chronic Obstructive Pulmonary Disease Is Superior to Traditional Exercise Training A Randomized Trial

作者：Klijn Peter^*; van Keimpema Anton; Legemaat Monique; Gosselink Rik; van Stel Henk

来源：American Journal of Respiratory and Critical Care Medicine, 2013, 188(2): 193-200.

DOI：10.1164/rccm.201210-1829OC

• chronic obstructive pulmonary disease
• exercise training
• periodization
• fat-free mass
• health-related quality of life

Rationale: The optimal exercise training intensity and strategy for individualized exercise training in chronic obstructive pulmonary disease (COPD) is not clear. %26lt;br%26gt;Objectives: This study compares the effects of nonlinear periodized exercise (NLPE) training used in athletes to traditional endurance and progressive resistance (EPR) training in patients with severe COPD. %26lt;br%26gt;Methods: A total of 110 patients with severe COPD (FEV1 32% predicted) were randomized to EPR or NLPE. Exercise training was performed three times per week for 10 weeks. The primary outcomes were cycling endurance time and health-related quality of life using the Chronic Respiratory Questionnaire. The difference in change between EPR and NLPE was assessed using linear mixed-effects modeling. %26lt;br%26gt;Measurements and Main Results: NLPE resulted in significantly greater improvements in cycling endurance time compared with EPR. The difference in change was +300.6 seconds (95% confidence interval [CI] = 197.2-404.2 s; P %26lt; 0.001). NLPE also resulted in significantly greater improvements in all domains of the Chronic Respiratory Questionnaire compared with EPR, ranging from 10.48 (95% CI = 0.19-0.78) for the domain, emotions, to 10.96 (95% CI = 0.57-1.35) for dyspnea. %26lt;br%26gt;Conclusions: NLPE results in greater improvements in cycle endurance and health-related quality of life in patients with severe COPD than traditional training methods. Clinical trial registered with www.trialregister.nl (The Netherlands Trial Register; NTR 1045).

• 出版日期2013-7-15