Azithromycin Reduces the Production of alpha-hemolysin and Biofilm Formation in Staphylococcus aureus

作者：Gui, Zhihong; Wang, Huafu; Ding, Ting; Zhu, Wei; Zhuang, Xiyi; Chu, Weihua^*

来源：Indian Journal of Microbiology, 2014, 54(1): 114-117.

DOI：10.1007/s12088-013-0438-4

• Staphylococcus aureus
• Azithromycin
• Biofilm
• alpha-hemolysin

Staphylococcus aureus causes a broad range of life-threatening diseases in humans. This bacterium produces a large number of extracellular virulence factors that are closely associated with specific diseases which are controlled by quorum sensing. In this study, we show that azithromycin was active against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranged from 32 to 64 mu g/mL. Azithromycin at subinhibitory concentration, markedly reduced the production of alpha-hemolysin at (1/16MIC, 1/8MIC) and biofilm formation at (1/16MIC, 1/8MIC), respectively. The results indicated that sub-inhibitory concentrations of azithromycin decreased the production of alpha-hemolysin and biofilm formation in MRSA in a dose-dependent manner. Therefore, azithromycin may be useful in the treatment of alpha-hemolysin producing and biofilm formation MRSA infections.

• 出版日期2014-3
• 单位中国药科大学