Association Between a Thyroid Hormone Receptor-alpha Gene Polymorphism and Blood Pressure but Not With Coronary Heart Disease Risk

作者：Goumidi Louisa; Gauthier Karine; Legry Vanessa; Mayi Therese Hervee; Houzet Alexia; Cottel Dominique; Montaye Michele; Proust Carole; Kee Frank; Ferrieres Jean; Arveiler Dominique; Ducimetiere Pierre; Staels Bart; Dallongeville Jean; Chinetti Giulia; Flamant Frederic; Amouyel Philippe; Meirhaeghe Aline^*

来源：American Journal of Hypertension, 2011, 24(9): 1027-1034.

DOI：10.1038/ajh.2011.94

• blood pressure
• coronary heart disease
• hypertension
• polymorphism
• thyroid hormone
• thyroid hormone receptor

BACKGROUND
Thyroid hormones (THs) exert multiple biological roles including effects on the cardiovascular system (lipid profile, blood pressure (BP) and cardiac output). The lipid-lowering actions of TH are mediated by the TH receptor-beta whereas the mechanisms explaining the BP variations concomitant with the thyroid disorders are less understood. As the TH receptor-alpha (TR-alpha) has been associated with many of TH actions on the cardiovascular system in mice models, we hypothesized that it could be involved in the latter. We thus tested whether polymorphisms in TR-alpha (THRA gene) could be associated with BP level variation. Secondarily, we tested for association with coronary heart disease (CHD) risk.
METHODS
We analyzed the associations between five THRA polymorphisms and (i) BP level in two population-based studies (MONICA Lille n = 1,155; MONICA Toulouse n = 1,170) and (ii) the risk of CHD in two case-control studies (Lille CHD n = 558 cases/568 controls; PRIME n = 527 cases/584 controls).
RESULTS
Individuals carrying the rs939348T allele had higher systolic BP (similar to+1.3 mm Hg) than CC individuals in both the MONICA Lille (P = 0.02) and Toulouse (P = 0.03) studies. The odds ratio (OR) for hypertension was 1.25 (P = 0.02) in the combined sample. Concerning the CHD risk, no significant association could be detected.
CONCLUSIONS
For the first time, our study showed associations between the THRA rs939348 polymorphism and systolic BP and the risk of hypertension but not with CHD, although we admit that the statistical power available to study any relationship with CHD was very limited. Further larger association studies are needed to confirm our findings.

• 出版日期2011-9