Modification of the cell adhesion and hydrophilic characteristics of poly(ether-ether-ketone) by 172-nm Xenon excimer radiation

作者：Okada Yukimasa^*; Furumatsu Takayuki; Miyazawa Shinichi; Fujii Masataka; Takahashi Hiroyuki; Kimura Hiroomi; Ozaki Toshifumi; Abe Nobuhiro

来源：Bio-medical Materials and Engineering, 2015, 25(2): 169-175.

DOI：10.3233/BME-151267

• Poly(ether-ether-ketone)
• UV-irradiation
• cytocompatibility

BACKGROUND: Poly-ether-ether-ketone (PEEK) has biomechanical and chemical properties that are excellent for biomedical applications; however, PEEK adhesion to bone or chondral tissue proceeds slowly due to poor hydrophilicity and other surface characteristics.
OBJECTIVE: We investigated the structural change, hydrophilicity, and cytocompatibility of a PEEK surface after 172-nm xenon excimer UV-irradiation.
METHODS: The surface characteristics before and after irradiation were evaluated by contact angle and ATR-FTIR measurements. Mouse osteoblast-like cells (MC3T3-E1) were cultured on PEEK plates and collected after 6, 12 and 24 h for cell adhesion analysis by crystal violet staining (CVS) and scanning electron microscopy (SEM).
RESULTS: UV-irradiation improved PEEK surface hydrophilicity, as indicated by a significant drop in water contact angle (p < 0.05). Irradiated PEEK showed additional peaks around 3370 cm(-1) and 1720 cm(-1), highlighting the generation of hydroxyl and carbonyl groups. CVS and SEM revealed improved adhesion to the PEEK surface after UV-irradiation.
CONCLUSION: Our results suggest that 172-nm UV-irradiated PEEK may be used in biomedical applications that require good cell adhesion.

• 出版日期2015