MRI tools for assessment of microstructure and nephron function of the kidney

作者：Xie Luke; Bennett Kevin M; Liu Chunlei; Johnson G Allan; Zhang Jeff Lei; Lee Vivian S

来源：American Journal of Physiology - Renal Fluid and Electrolyte Physiology, 2016, 311(6): F1109-F1124.

DOI：10.1152/ajprenal.00134.2016

• magnetic resonance imaging
• kidney microstructure
• quantitative susceptibility mapping
• susceptibility tensor imaging
• kidney concentrating mechanism
• gadolinium-based contrast agent
• cationized ferritin agents
• glomerular microstructure
• nephron architecture

MRI can provide excellent detail of renal structure and function. Recently, novel MR contrast mechanisms and imaging tools have been developed to evaluate microscopic kidney structures including the tubules and glomeruli. Quantitative MRI can assess local tubular function and is able to determine the concentrating mechanism of the kidney noninvasively in real time. Measuring single nephron function is now a near possibility. In parallel to advancing imaging techniques for kidney microstructure is a need to carefully understand the relationship between the local source of MRI contrast and the underlying physiological change. The development of these imaging markers can impact the accurate diagnosis and treatment of kidney disease. This study reviews the novel tools to examine kidney microstructure and local function and demonstrates the application of these methods in renal pathophysiology.

• 出版日期2016-12-1