Microwave assisted synthesis of 2-(2-(tetrazolo[1,5-a]quino-lin-4-yl)-2,3-dihydro-1H-1,5-benzodiazepin-4 -yl) substituted phenols and evaluation of their antimicrobial activity

作者：Ashok Dongamanti^*; Rao Velagapuri Hanumantha; Kavitha Rangu

来源：Journal of the Serbian Chemical Society, 2016, 81(8): 851-858.

DOI：10.2298/JSC150504041A

• Antimicrobial activity
• benzodiazepines
• chalcones
• Michael addition
• microwave irradiation
• tetrazoloquinoline aldehyde

A series of new benzodiazepines 4a-h were synthesized by Michael addition of chalcones 3a-h with o-phenylenediamine (OPDA) in presence of sodium acetate under conventional heating and microwave irradiation. The structures of the newly synthesized benzodiazepines were established based on IR, H-1- and C-13-NMR and mass spectral data and tested for their antimicrobial activity.

• 出版日期2016