A Nucleophilic Strategy for Enantioselective Intermolecular alpha-Amination: Access to Enantioenriched alpha-Arylamino Ketones

作者:Miles Dillon H; Guasch Joan; Toste F Dean*
来源:Journal of the American Chemical Society, 2015, 137(24): 7632-7635.
DOI:10.1021/jacs.5b04518

摘要

The enantioselective addition of anilines to azoalkenes, was accomplished through the use of a chiral phosphoric acid catalyst. The resulting alpha-arylamino hydrazones were obtained in good yields and excellent enantioselectivities and provide access to enantioenriched alpha-arylamino ketones. A serendipitous kinetic resolution of racemic alpha-arylamino hydrazones is also described.

  • 出版日期2015-6-24