A [4+1] Cyclative Capture Access to Indolizines via Cobalt(III)-Catalyzed Csp(2)-H Bond Functionalization

作者：Chen, Xun; Hu, Xinwei; Deng, Yuanfu; Jiang, Huanfeng; Zeng, Wei^*

来源：Organic Letters, 2016, 18(18): 4742-4745.

DOI：10.1021/acs.orglett.6b02421

• C-H BOND
• TERMINAL ALKYNES
• CARBENOID FUNCTIONALIZATION
• INTERNAL ALKYNES
• INDOLE SYNTHESIS
• FACILE SYNTHESIS
• DIAZO-COMPOUNDS
• ONE-POT
• ACTIVATION
• ALDEHYDES

A Co(III)-catalyzed [4 + 1] cycloaddition of 2-arylpyridines or 2-alkenylpyridines with aldehydes through Csp(2)-H bond activation has been developed. This protocol provides a facile approach to structurally diverse indolizines including benzoindolizines with a broad range of functional group tolerance.

• 出版日期2016-9-16
• 单位华南理工大学