Advances in Decarboxylative Oxidative Coupling Reaction

作者：Zhang, Tong; Wang, Nai-Xing^*; Xing, Yalan^*

来源：Journal of Organic Chemistry, 2018, 83(15): 7559-7565.

DOI：10.1021/acs.joc.8b01080

• ALPHA-OXOCARBOXYLIC ACIDS
• METAL-FREE CONDITIONS
• H BOND ACTIVATION
• CARBOXYLIC-ACIDS
• ORTHO-ACYLATION
• CINNAMIC-ACIDS
• TRANSITION-METAL
• BENZOIC-ACIDS
• FACILE SYNTHESIS
• RADICAL PROCESS

Since carboxylic acid derivatives are commercially available, nontoxic, cheap, and normally stable to air and moisture, carboxylic acid derivatives are ideal reactants for synthetic strategy. In recent years, decarboxylative oxidative coupling reactions, which normally involve direct C-H bond activation, have attracted more and more interest from the synthetic community. Compared with conventional methods, this strategy is more environmentally friendly and step-economic. This review mainly focuses on recent advances of the decarboxylative oxidative coupling reaction.

• 出版日期2018-8-3
• 单位中国科学院大学