Dose Response Effects of Lisdexamfetamine Dimesylate Treatment in Adults With ADHD: An Exploratory Study

作者：Faraone Stephen V^*; Spencer Thomas J; Kollins Scott H; Glatt Stephen J; Goodman David

来源：Journal of Attention Disorders, 2012, 16(2): 118-127.

DOI：10.1177/1087054711403716

• ADHD
• dose-response
• lisdexamfetamine dimesylate
• amphetamine
• stimulants

Objective: To explore dose-response effects of lisdexamfetamine dimesylate (LDX) treatment for ADHD. Method: This was a 4-week, randomized, double-blinded, placebo-controlled, parallel-group, forced-dose titration study in adult participants, aged 18 to 55 years, meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.) criteria for ADHD. Results: Nearly all participants assigned to an LDX dose achieved their assigned dose with the exception of about 4% of participants assigned to the 50 mg or 14% assigned to the 70 mg doses. Higher doses of LDX led to greater improvements in ADHD-rating scale scores, independent of prior pharmacotherapy. This was evident for both inattentive and hyperactive-impulsive symptoms. The authors found some evidence for an interaction between LDX dose and baseline severity of ADHD symptoms. Conclusion: For LDX doses between 30 and 70 mg/d, the dose-response efficacy effect for LDX is not affected by prior pharmacotherapy, but patients with a greater severity of illness may benefit more from higher doses, especially for hyperactive-impulsive symptoms. The results do not provide information about doses above 70 mg/d, which is the maximum approved dose of LDX and the highest dose studied in ADHD clinical trials. (J. of Att. Dis. 2012; 16(2) 118-127)

• 出版日期2012-2