Acute Lymphoblastic Leukemia Presenting With Pancytopenia Followed by a 14-Month-Long Period of Transient Remission Possibly Supporting the Adrenal Hypothesis of Leukemogenesis

作者：Lynggaard Line Stensig; Marquart Hanne V; Kjeldsen Eigil; Madsen Hans O; Hasle Henrik^*

来源：Journal of Pediatric Hematology/Oncology, 2016, 38(8): E271-E273.

DOI：10.1097/MPH.0000000000000648

• acute lymphoblastic leukemia
• pancytopenia
• transient remission
• etiology
• pathogenesis

A small group of children with acute lymphoblastic leukemia (ALL) have a preleukemic phase of pancytopenia followed by a period of spontaneous remission before the diagnosis (pre-ALL). A 6-year-old girl presented with pancytopenia, fever, and myelodysplasia. Following transient remission pre-B ALL was diagnosed 14 months later. Clonal B-lineage blasts at the period of pancytopenia were identified retrospectively. The interval between pre-ALL and ALL-diagnosis was longer than previously reported. The infection was clinically severe and might have induced a significant endogenous corticosteroids production resulting in the long-lasting remission. The case supports the adrenal and the Coley's toxin hypothesis in leukemogenesis.

• 出版日期2016-11