科研之友
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摘要
Molecular mediation of singlet oxygen generation is demonstrated based on a newly engineered aptamer probe. Both ATP and human a-thrombin aptamers were engineered to testify to this design, and both showed that the production of singlet oxygen can be triggered and quantitatively mediated by the presence of target molecules. Moreover, both photosensitizer aptamer switch (PAS) probes showed excellent selectivity toward their targets. These results suggest that a PAS can serve as a smart photodynamic therapy agent.
- 出版日期2010
