Modification of well-aligned carbon nanotubes with dihexadecyl hydrogen phosphate: application to highly sensitive nanomolar detection of simvastatin

作者：Fayazfar H; Afshar A; Dolati A^*; Ghalkhani M

来源：Journal of Applied Electrochemistry, 2014, 44(2): 263-277.

DOI：10.1007/s10800-013-0654-y

• Voltammetry
• Electrochemical oxidation
• Simvastatin
• Sensors
• Multi-walled carbon nanotube

The first usage of dihexadecyl hydrogen phosphate (DHP)-modified highly oriented multi-walled carbon nanotube (MWCNTs) forests in a sensor configuration was developed to investigate the electrochemical oxidation and determination of simvastatin (SV) in pharmaceutical dosage forms. Synthesis of well-aligned MWCNTs on a conductive Ta substrate by catalytic vapor deposition technique using a common chemical, ethylenediamine, and without being plasma-aided was reported. The electrochemical behavior and oxidation of SV at the aligned MWCNTs/DHP/Ta electrode were discussed in detail through cyclic voltammetry and differential pulse voltammetry. This modified electrode showed considerably higher electrocatalytic activity for SV than bare Ta electrode or entangled MWCNTs powder electrode, due to presence of the alignment and mutual separation of CNTs. Under the optimal conditions, the A-MWCNTs/DHP/Ta-modified electrode showed a wide linear range from 0.01 to 1 mu M with a detection limit of 0.01 nM demonstrating promising results for the future usage in clinical applications.

• 出版日期2014-2