Antiviral activity of Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis against respiratory syncytial virus

作者：Agbo Matthias Onyebuchi^*; Odimegwu Damian Chukwu; Okoye Festus Basden Chiedu; Osadebe Patience Ogoamaka

来源：Pakistan Journal of Pharmaceutical Sciences, 2017, 30(4): 1251-1256.

• hRSV
• Loranthus micranthus Linn
• Salidroside
• structure elucidation
• anti-hRSV activity

Isolated Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis was evaluated for its antiviral activity against respiratory syncytial virus. Semi-preparative HPLC separation of the ethyl acetate fraction of the leave extract of Loranthus micranthus Linn parasitic on Hevea brasiliensis led to the isolation of a polyphenol. Using spectroscopic methods (1D and 2D NMR and mass spectroscopic data) as well as by comparison with literature data the structure of the compound was determined as 6-O-galloyl salidroside. The antiviral activity of the isolated compound was evaluated against the respiratory syncytial virus. The isolated Salidroside showed potent inhibition towards a recombinant straining respiratory syncytial virus with Inhibitory Concentration (IC50) value of 10.3 +/- 1.50 mu g/mL. The result indicates that Salidroside is an efficient antiviral agent against RSV infection and might be useful for the management of RSV pathogenesis.

• 出版日期2017-7