Application of fibrin sealant in patients operated on for differentiated thyroid cancer. What do we improve?

作者：Vidal Perez Oscar^*; Flores Siguenza Luis; Valentini Mauro; Astudillo Pombo Emiliano; Fernandez Cruz Laureano; Carlos Garcia Valdecasas Juan

来源：Cirugia y Cirujanos, 2016, 84(4): 282-287.

DOI：10.1016/j.circir.2015.02.004

• Fibrin tissue adhesive
• Thyroidectomy
• Lymph node excision

Background: In recent years, several publications have shown that new adhesives and sealants, like Tissucol applied in thyroid space reduce local complications after thyroidectomies.
Study aims: To demonstrate the effectiveness of fibrin glue Tissucol in reducing the postoperative hospital stay of patients operated on for differentiated thyroid carcinoma in which total thyroidectomy with central and unilateral node neck dissection was performed (due to the debit drains decrease), with consequent cost savings.
Material and methods: A prospective randomised study was conducted during the period between May 2009 and October 2013 on patients with differentiated thyroid carcinoma with cervical nodal metastases, and subjected to elective surgery. Two groups were formed: one in which Tissuco (R) was used (case group) and another where it was not used (control group). Patients were operated on by surgeons specifically dedicated to endocrine surgical pathology, using the same surgical technique in all cases.
Results: A total of 60 total thyroidectomies with lymph node dissection were performed, with 30 patients in the case group, and 30 patients in control group. No statistically significant differences were observed in most of the studied variables. However, the case group had a shorter hospital stay than the control group with a statistically significant difference (p < 0.05).
Conclusion: Implementation of Tissucol has statistically and significantly reduced the hospital stay of patients undergoing total thyroidectomy with neck dissection, which represents a significant reduction in hospital costs. This decrease in hospital stay has no influence on the occurrence of major complications related to the intervention.

• 出版日期2016-8