Microbleed Burden and Hematoma Expansion in Acute Intracerebral Hemorrhage

作者：Marti Fabregas Joan^*; Delgado Mederos Raquel; Granell Esther; Morenas Rodriguez Estrella; Marin Lahoz Juan; Dinia Lavinia; Carrera David; Perez de la Ossa Natalia; Sanahuja Jordi; Sobrino Tomas; Maria De Arce Ana; Alonso de Lecinana Maria

来源：European Neurology, 2013, 70(3-4): 175-178.

DOI：10.1159/000351246

• Microbleed
• Intracerebral hemorrhage
• Hematoma expansion
• Arterial hypertension
• Amyloid angiopathy
• Magnetic resonance

Background: Intracranial amyloid and hypertensive angiopathy have been related to impaired blood vessel function and the etiology of intracerebral hemorrhage (ICH). Microbleeds (MBs) are surrogate radiological markers that are associated with these underlying angiopathies. We assessed the hypothesis that MBs are associated with hematoma expansion (HE) in patients with hyperacute ICH. Methods: We studied patients with spontaneous supratentorial ICH within the first 6 h after onset. HE was defined as an increase %26gt;= 33% in the volume of hematoma on the follow-up CT in comparison with the admission CT. The volume was calculated using the ABC/2 formula. MBs were detected by specific magnetic resonance sequences (gradient-echo). The presence, number and distribution of MBs were analyzed. Results: Our study included 44 patients. Their mean age was 68.9 +/- 11.1 years, and 70.5% of them were men. HE was observed in 14 of the patients (31.8%). HE was more prevalent in patients with more than 10 MBs compared with patients with 1-10 MBs (60 vs 12.5%; p = 0.03). Conclusion: A high burden of MBs is associated with an increased risk of HE in patients with ICH. This is probably a marker of a more severe underlying angiopathy.

• 出版日期2013