Arsenic trioxide-loaded pH-responsive mesoporous silica nanoparticles:preparation, in vitro release and pharmacokinetic studies in rats

作者：ManmanGuo; GuoweiWang; JianiGuan; JunjunXu; FanzhuLi

来源：2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会, China,Hunan,Changsha, 2014-09-21.

• arsenic trioxide
• PAA-MSNs
• in vitro release
• pharmacokinetic

　　Objective To prepare arsenic trioxide-loaded pH-responsive mesoporous silica nanoparticles (PAA-ATO-MSNs) and investigate their physicochemical properties, release behavior in vitro and pharmacokinetics in rats, in order to achieve pH-responsive and sustained release of PAA-MSNs as carrier for ATO.

• 出版日期2017