Ability of a Genomic Classifier to Predict Metastasis and Prostate Cancer-specific Mortality after Radiation or Surgery based on Needle Biopsy Specimens

作者：Nguyen Paul L^*; Haddad Zaid; Ross Ashley E; Martin Neil E; Deheshi Samineh; Lam Lucia L C; Chelliserry Jijumon; Tosoian Jeffrey J; Lotan Tamara L; Spratt Daniel E; Stoyanova Radka S; Punnen Sanoj; Ong Kaye; Buerki Christine; Aranes Maria; Kolisnik Tyler; Margrave Jennifer; Yousefi Kasra; Choeurng Voleak; Davicioni Elai; Trock Bruce J; Kane Christopher J; Pollack Alan; Davis John W; Feng Felix Y; Klein Eric A

来源：European Urology, 2017, 72(5): 845-852.

DOI：10.1016/j.eururo.2017.05.009

• Biopsy
• Prostate cancer-specific mortality
• Metastasis
• Genomics

Background: Decipher is a validated genomic classifier developed to determine the biological potential for metastasis after radical prostatectomy (RP).
Objective: To evaluate the ability of biopsy Decipher to predict metastasis and Prostate cancer-specific mortality (PCSM) in primarily intermediate- to high-risk patients treated with RP or radiation therapy (RT).
Design, setting, and participants: Two hundred and thirty-five patients treated with either RP (n = 105) or RT +/- androgen deprivation therapy (n = 130) with available genomic expression profiles generated from diagnostic biopsy specimens from seven tertiary referral centers. The highest-grade core was sampled and Decipher was calculated based on a locked random forest model.
Outcome measurements and statistical analysis: Metastasis and PCSM were the primary and secondary outcomes of the study, respectively. Cox analysis and c-index were used to evaluate the performance of Decipher.
Results and limitations: With a median follow-up of 6 yr among censored patients, 34 patients developed metastases and 11 died of prostate cancer. On multivariable analysis, biopsy Decipher remained a significant predictor of metastasis (hazard ratio: 1.37 per 10% increase in score, 95% confidence interval [CI]: 1.06-1.78, p = 0.018) after adjusting for clinical variables. For predicting metastasis 5-yr post-biopsy, Cancer of the Prostate Risk Assessment score had a c-index of 0.60 (95% CI: 0.50-0.69), while Cancer of the Prostate Risk Assessment plus biopsy Decipher had a c-index of 0.71 (95% CI: 0.60-0.82). National Comprehensive Cancer Network risk group had a c-index of 0.66 (95% CI: 0.53-0.77), while National Comprehensive Cancer Network plus biopsy Decipher had a c-index of 0.74 (95% CI: 0.66-0.82). Biopsy Decipher was a significant predictor of PCSM (hazard ratio: 1.57 per 10% increase in score, 95% CI: 1.03-2.48, p = 0.037), with a 5-yr PCSM rate of 0%, 0%, and 9.4% for Decipher low, intermediate, and high, respectively.
Conclusions: Biopsy Decipher predicted metastasis and PCSM from diagnostic biopsy specimens of primarily intermediate- and high- risk men treated with first-line RT or RP.
Patient summary: Biopsy Decipher predicted metastasis and prostate cancer-specific mortality risk from diagnostic biopsy specimens.

• 出版日期2017-11