Anti-inflammatory properties of resveratrol in the retinas of type 2 diabetic rats

作者：Soufi Farhad Ghadiri^*; Arbabi Aval Elham; Kanavi Mozhgan Rezaei; Ahmadieh Hamid

来源：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2015, 42(1): 63-68.

DOI：10.1111/1440-1681.12326

• diabetic retinopathy
• nuclear factor-B
• polyphenol
• resveratrol
• streptozotocin-nicotinamide model

Resveratrol (trans-3,5,4-trihydroxystilbene) is a nutritional supplement with anti-inflammatory properties. The present study investigated the long-term anti-inflammatory property of resveratrol in the retinas of type 2 diabetic rats. Male Wistar rats were divided into four groups: normal control, diabetic control, resveratrol-treated normal rats and resveratrol-treated diabetic rats. Type 2 diabetes was induced by a single dose injection of streptozotocin (50mg/kg; i.p.) 15min after the administration of nicotinamide (110mg/kg; i.p.) in 12-h fasted rats (the streptozotocin-nicotinamide type 2 diabetic model). Oral resveratrol administration (5mg/kg per day for 4months) significantly improved glucose tolerance, and alleviated hyperglycemia and weight loss in diabetic rats. Furthermore, resveratrol administration significantly decreased the elevated levels of nuclear factor-B activity, and mRNA expression, tumour necrosis factor alpha level and apoptotic cells in the retinas of the diabetic rats. Furthermore, resveratrol did not significantly affect plasma insulin levels. Long-term resveratrol administration has beneficial anti-inflammatory properties in a rat model of diabetes. However, whether resveratrol exerts its effects directly or through reducing blood glucose levels requires further investigation.

• 出版日期2015-1