Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms

作者：Hellstrom Ingegerd^*; Heagerty Patrick J; Swisher Elizabeth M; Liu Pu; Jaffar Jade; Agnew Kathy; Hellstrom Karl Erik

来源：Cancer Letters, 2010, 296(1): 43-48.

DOI：10.1016/j.canlet.2010.03.013

• ELISA
• Ovarian cancer diagnostics
• Urine
• HE4

The HE4 protein is overexpressed in ovarian carcinomas and can be detected in serum by an ELISA with sensitivity similar to CA125 and higher specificity for malignant disease. We now demonstrate that HE4 can also be detected in the urine at a specificity level of 94.4%, including 13/15 (86.6%) with stage I/II and 57/64 (89.0%) with stage III/IV disease and including 90.5% of patients with serous ovarian carcinoma. Assaying serum and urine from the same patients showed similar sensitivity. Our data indicate that measuring HE4 in urine may aid diagnosis and the monitoring of response to therapy.

• 出版日期2010-10-1