Microbial beta gamma-crystallins

作者：Mishra Amita; Krishnan Bal; Srivastava Shanti Swaroop; Sharma Yogendra^*

来源：Progress in Biophysics and Molecular Biology, 2014, 115(1): 42-51.

DOI：10.1016/j.pbiomolbio.2014.02.007

• beta gamma-Crystallins
• beta gamma Domain
• Greek key motif
• Ca2+-binding
• Microbial relatives
• Evolution

beta gamma-Crystallins have emerged as a superfamily of structurally homologous proteins with representatives across the domains of life. A major portion of this superfamily is constituted by members from microorganisms. This superfamily has also been recognized as a novel group of Ca2+-binding proteins with huge diversity. The beta gamma domain shows variable properties in Ca2+ binding, stability and association with other domains. The various members present a series of evolutionary adaptations culminating in great diversity in properties and functions. Most of the predicted beta gamma-crystallins are yet to be characterized experimentally. In this review, we outline the distinctive features of microbial beta gamma-crystallins and their position in the beta gamma-crystallin superfamily.

• 出版日期2014-7