A mesoporous silica/fluorinated alcohol adduct: an efficient metal-free, three-component synthesis of indazolophthalazinetrione heterocycles using a reusable nanoporous/trifluoroethanol adduct (SBA-15/TFE)

作者：Rostamnia Sadegh^*; Doustkhah Esmail

来源：Tetrahedron Letters, 2014, 55(15): 2508-2512.

DOI：10.1016/j.tetlet.2014.03.019

• Multicomponent reaction
• Trifluoroethanol
• SBA-15
• Indazolophthalazinetriones

The channels of mesoporous (SBA-15) represent a straightforward reactor for the rapid synthesis of indazolophthalazinetrione skeletons via three-component coupling reactions in 2,2,2-trifluoroethanol. The solid SBA-15 and TFE could be recovered and reused. The present method carries the advantage of being performed under neutral conditions and requires no activation or modification of the substrates.

• 出版日期2014-4-9