Duration of Cisplatin Excretion in Breast Milk

作者：Hays Karen E; Ryu Rachel J; Swisher Elizabeth M; Reed Eddie; McManus Terry; Rybeck Blanche; Petros William P; Hebert Mary F^*

来源：Journal of Human Lactation, 2013, 29(4): 469-472.

DOI：10.1177/0890334413479671

• breastfeeding
• breast milk
• cisplatin
• human milk

Cisplatin, a platinum-based chemotherapy agent, is commonly used in treating cancers that may affect women of childbearing age, including cervical cancer, triple-negative breast cancer, and pediatric tumors in adolescents. The authors found that platinum was undetectable in breast milk at 66 hours and beyond following a 70-mg dose of intravenous cisplatin. Relative infant dose of platinum was calculated to be between 0.29% and 0.40% of the maternal dose corrected for body weight. This case demonstrates minimal exposure to platinum via breast milk, following a single 70-mg intravenous dose of cisplatin.

• 出版日期2013-11