Amino acid and carbohydrate preferences in C57BL/6ByJ and 129P3/J mice

作者：Bachmanov Alexander A^*; Beauchamp Gary K

来源：Physiology & Behavior, 2008, 93(1-2): 37-43.

DOI：10.1016/j.physbeh.2007.07.016

• inbred mice
• genetics
• nutrient
• intake
• consumption
• appetite
• sweet
• taste

Compared with mice from the 129P3/J (129) inbred strain, mice from the C57BL/6ByJ (B6) inbred strain have higher consumption of several sweet-tasting amino acids and carbohydrates. To examine the relative contribution of taste and nutritive properties in these strain differences, we measured responses of 136 and 129 mice to eight sweet and non-sweet amino acids and carbohydrates in two-bottle preference tests with water. Mice from the two strains did not differ in consumption of non-sweet L-valine and L-histidine. Compared with 129 mice, 136 mice had higher consumption and lower preference thresholds for sweet amino acids L-glutamine, L-alanine and L-threonine, monosaccharides glucose and fructose, and maltooligosaccharide. These data suggest that differences in gustatory responsiveness are an important factor underlying higher consumption of some amino acids and carbohydrates by 136 mice compared with 129 mice. It is likely that in B6 mice, higher sweet taste responsiveness results in increased consumption of sweet-tasting amino acids and sugars, and. higher taste responsiveness to complex carbohydrates results in increased consumption of maltooligosaccharide. However, postingestive processes also influence nutrient consumption and may be responsible for higher intake of carbohydrates compared with sweet-tasting amino acids. Results of this study set the stage for genetic analysis of differences between B6 and 129 mice in taste responsiveness and macronutrient consumption.

• 出版日期2008-1-28