A randomised crossover study of low-flow air or oxygen via nasal cannulae to prevent desaturation in preterm infants

作者：Hensey Conor C; Hayden Eoghan; O' Donnell Colm Patrick Finbarr

来源：Archives of Disease in Childhood - Fetal and Neonatal Edition, 2013, 98(5): F388-F391.

DOI：10.1136/archdischild-2012-302623

• Infant
• Newborn
• Premature
• Respiration
• Oxygen
• Randomised

Objective %26lt;br%26gt;To compare the efficacy of low-flow oxygen, low-flow air and sham treatment given via nasal cannulae in preventing desaturation (falls in oxygen saturation (SpO(2))) in preterm infants. %26lt;br%26gt;Study design %26lt;br%26gt;Infants born at %26lt;33weeks gestation receiving gas at flow rates %26lt;1l/min via nasal cannulae were eligible for inclusion. Enrolled infants received three treatments0.1l/min 100% oxygen, 0.1l/min air, (21% oxygen) and sham (tubing disconnected from flow-meter)via nasal cannulae, each for 3h. Treatments were given in a randomly assigned order and caregivers were masked to treatment. Infants were monitored with a pulse oximeter that recorded SpO(2) and heart rate every 2s. Treatment was stopped before 3h if infants reached prespecified failure criteria. We compared the rates of failure and the frequency and duration of desaturation episodes that occurred during each treatment. %26lt;br%26gt;Results %26lt;br%26gt;Of 14 infants enrolled, 2 (14%) reached failure criteria during treatment with oxygen compared with 7 (50%) during treatment with air and sham. Among infants who completed the 3-h study periods, there were fewer episodes and shorter duration of desaturation with oxygen compared with air and sham. %26lt;br%26gt;Conclusions %26lt;br%26gt;At a flow rate of 0.1l/min via nasal cannulae, air is no better than sham treatment in preventing desaturation in preterm infants, while 100% oxygen is superior to both.

• 出版日期2013-9