Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response

作者：Yip Sarah W^*; DeVito Elise E; Kober Hedy; Worhunsky Patrick D; Carroll Kathleen M; Potenza Marc N

来源：Drug and Alcohol Dependence, 2016, 166: 134-142.

DOI：10.1016/j.drugalcdep.2016.07.006

• Medication
• Cocaine
• Heroin
• Opioids
• Methadone
• Polysubstance use

Background: Cocaine dependence among opioid-dependent methadone-maintained individuals is a significant public health problem and is particularly challenging to treat. The neurobiology of this clinically complex population has not been previously assessed using fMRI.
Methods: fMRI data from cocaine-dependent, methadone-maintained (CD-MM) patients (n = 24), cocaine dependent (CD) patients (n = 20) and healthy comparison (HC) participants (n = 21) were acquired during monetary incentive delay task performance. All patients were scanned prior to treatment for cocaine dependence. Between-group differences in anticipatory reward and loss processing were assessed using whole-brain ANOVAs in SPM12 (pFWE < 0.05). Correlations between durations of abstinence during treatment and BOLD responses within the insula and caudate were also explored.
Results: Main effects of diagnostic group, primarily involving decreased BOLD responses among CD MM patients in comparison to HCs, were observed during anticipatory reward and loss processing within regions of posterior cingulate cortex, precuneus, inferior frontal gyrus and dorsolateral prefrontal cortex. BOLD responses within the right caudate were negatively associated with percentage of cocaine negative urines during treatment among CD-MM patients, but not among non-methadone-maintained CD patients.
Conclusions: These data suggest neurofunctional differences that may be related to treatment outcomes for behavioral therapies between cocaine-dependent individuals with and without methadone maintenance treatment. These findings may relate to differences in treatment efficacies and to the elevated relapse rates observed in methadone-maintained populations.

• 出版日期2016-9-1