Epithelial and endothelial barriers in human disease

作者:Mullin JM*; Agostino N; Rendon Huerta E; Thornton JJ
来源:Drug Discovery Today, 2005, 10(6): 395-408.
DOI:10.1016/S1359-6446(05)03379-9

摘要

There is a spectrum of distinct disease states that have in common their effect of breaking down epithelial and/or endothelial barrier function Fluid. compartmentalization goes awry, with profound implications for epithelial and stromal homeostasis, fluid and/or electrolyte balance generation of inflammatory states, and even tumor microenvironment. Specific effects on the tight junction are found to be integral to bacterial invasion and tumor progression.