A light/dark cycle in the NICU accelerates body weight gain and shortens time to discharge in preterm infants

作者：Vasquez Ruiz Samuel; Alfonso Maya Barrios Jose; Torres Narvaez Patricia; Ruben Vega Martinez Benito; Rojas Granados Adelina; Escobar Carolina; Angeles Castellanos Manuel^*

来源：Early Human Development, 2014, 90(9): 535-540.

DOI：10.1016/j.earlhumdev.2014.04.015

• Circadian rhythms
• Chronotherapy
• Melatonin
• Neonatology

Background: Bright constant light levels in the NICU may have negative effects on the growth and development of preterm infants
Objective: The aim of this study is to evaluate the benefits of an alternating light/dark cycle in the NICU on weight gain and early discharge from the therapy in premature infants.
Patients and methods: A randomized interventional study was designed comparing infants in the NICU of Hospital Juarez de Mexico, exposed from birth either to an LD environment (LD, is n = 19) or to the traditional continuous light (LL, n = 19). The LD condition was achieved by placing individual removable helmets over the infant's heads. Body weight gain was analyzed, as the main indicator of stability and the main criteria for discharge in preterm infants born at 31.73 +/- 0.31 week gestational age.
Results: Infants maintained in an LD cycle gained weight faster than infants in LL and therefore attained a shorter hospital stay, (34.37 +/- 3.12 vs 51.11 +/- 529 days; P > 0.01). Also, LD infants exhibited improved oxygen saturation and developed a daily melatonin rhythm.
Conclusions: These findings provide a convenient alternative for establishing an LD environment for preterm healthy newborns in the NICU and confirm the beneficial effects of an alternating LD cycle for growth and weight gain and for earlier discharge time. Here we provide an easy and practical alternative to implement light/dark conditions in the NICU.

• 出版日期2014-9