科研之友
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摘要
Chiral chromans and flavanones derivatives are widely exist in plants, asymmetric synthesis of biological active chiral flavanone and chromanone derivatives is a valuable research field. A chroman derivatived (+)-(S, R, R, R)-Nebivolol (1-adrenergic receptor blocker) has been synthesized by natural chiron and sulfoxide-directed method recently. Enantioselective method for the synthesis of flavanones and chromanones by the oxa-Michael addition and other cyclization reactions are described, asymmetric Michael-Michael cascade reaction for the construction of chiral chromans provideas a novel method in the synthesis of chiral flavanones and chromanones. Trost's AAA reaction (Pd-catalyzed asymmetric allylic alkylation) provides a novel strategies in the synthesis of flavanones and chromanones.
- 出版日期2013-7
- 单位北京化工大学; 中国科学院理化技术研究所
