Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascin-positive/-negative Head and Neck Squamous Cell Carcinoma

Zivicova Veronika; Gal Peter<sup>*</sup>; Mifkova Alzbeta; Novak Stepan; Kaltner Herbert; Kolar Michal; Strnad Hynek; Sachova Jana; Hradilova Miluse; Chovanec Martin; Gabius Hans Joachim; Smetana Karel Jr; Fik Zdenek<sup>*</sup>

doi:10.21873/anticanres.12350

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Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascin-positive/-negative Head and Neck Squamous Cell Carcinoma

作者：Zivicova Veronika; Gal Peter^*; Mifkova Alzbeta; Novak Stepan; Kaltner Herbert; Kolar Michal; Strnad Hynek; Sachova Jana; Hradilova Miluse; Chovanec Martin; Gabius Hans Joachim; Smetana Karel Jr; Fik Zdenek^*

来源：Anticancer Research, 2018, 38(3): 1279-1290.

DOI：10.21873/anticanres.12350

摘要

Background/Aim: Having previously initiated genome-wide expression profiling in head and neck squamous cell carcinoma (HNSCC) for regions of the tumor, the margin of surgical resecate (MSR) and normal mucosa (NM), we here proceed with respective analysis of cases after stratification according to the expression status of tenascin (Ten). Materials and Methods: Tissue specimens of each anatomical site were analyzed by immunofluorescent detection of Ten, fibronectin (Fn) and galectin-1 (Gal-1) as well as by microarrays.