Aerobic oxysulfonylation of alkynes in aqueous media: highly selective access to beta-keto sulfones

作者：Singh Atul K; Chawla Ruchi; Yadav Lal Dhar S^*

来源：Tetrahedron Letters, 2014, 55(17): 2845-2848.

DOI：10.1016/j.tetlet.2014.03.078

• Alkynes
• Sodium arenesulfinates
• FeCl3/K2S2O8 catalysis
• Radical aerobic oxysulfonylation
• beta-Keto sulfones

The first application of inexpensive commercially available sulfinate salts to produce beta-keto sulfones directly from allcynes via aerobic oxysulfonylation has been developed. It is a highly selective (undesired Glaser Hay homo-coupling and ATRA process totally suppressed) general method of functionalization of alkynes on water at room temperature involving FeCl3/K2S2O8 catalyzed formation of sulfonyl radicals from sulfinate salts.

• 出版日期2014-4-23